診療実績(京都大学医学部附属病院)

京都大学医学部附属病院手術統計

主な診療対象疾患
- 虚血性心疾患(狭心症、急性心筋梗塞、 心室瘤)
- 弁膜症(僧帽弁狭窄、僧帽弁閉鎖不全、大動脈弁狭窄、大動脈弁閉鎖不全、 三尖弁閉鎖不全)
- 大動脈疾患(胸部大動脈瘤、急性大動脈解離、解離性大動脈瘤、胸腹部大動脈瘤、腹部大動脈瘤)
- 心筋症(虚血性心筋症、拡張型心筋症、肥大型心筋症)
- 先天性心疾患(心房中隔欠損、心室中隔欠損、動脈管開存、ファロー四徴、完全型房室中隔欠損、大血管転位、総肺静脈還流異常、単心室)
- 末梢血管疾患(閉塞性動脈硬化症、バージャー病、下肢静脈瘤)
- その他(心臓腫瘍、心房細動、収縮性心膜炎)
診療体制と実績
- 1)外来診療体制と実績
平成23年ののべ外来患者数は5,320人(前年比23%増)、このうち初診患者数は399人(紹介率85.5%)であり、高い紹介率を維持した。 一般外来、初診外来に加え、小児心臓外来(奇数週金曜日)、重症心不全外来(毎週火曜日)、大動脈瘤・ステント外来(毎週火曜日)、下肢静脈瘤外来(毎週水曜日)の専門外来診療を行っている。 - 2)入院診療体制と実績
平成23年ののべ入院患者数は7,535人で前年と比較して横ばいであったが、平均在院日数は14.5日と前年と比べて1.7日の短縮であった。総手術件数は心臓、大血管、末梢血管すべて合わせて316件であり、前年と比べ約11%増加した。
学術業績(京都大学医学部附属病院)
2023年 2022年 2021年 2020年 2019年 2018年 2017年
- 2023年
- 1.Osada H, Yamazaki K, Suzuki T, Tomotsuka S, Sugimoto A, Fujimoto M, Minatoya K. Cardiac capillary hemangioma originating from the mitral valve. JTCVS Tech. 2023 May 25;20:127-129. doi: 10.1016/j.xjtc.2023.05.002. eCollection 2023 Aug.
- 2.Minatoya K. To keep a balance, we must keep moving. Eur J Cardiothorac Surg. 2023 Apr 3;63(4):ezad150. doi: 10.1093/ejcts/ezad150.
- 3.Ide Y, Ikeda T, Tomotsuka S, Matsuda K, Akagi K, Hirata T, Baba S, Minatoya K. Influence of the bronchus on the vascular growth of major aortopulmonary collateral arteries. Interdiscip Cardiovasc Thorac Surg. 2023 Apr 3;36(4):ivad001. doi: 10.1093/icvts/ivad001.
- 4.Osada H, Takeda T, Kanemitsu H, Yamazaki K, Tsujimura M, Fujimoto M, Minatoya K. Multiple papillary fibroelastoma originating from 3 leaflets of the aortic valve. JTCVS Tech. 2023 Jul 20;21:62-64. doi: 10.1016/j.xjtc.2023.07.003. eCollection 2023 Oct.
- 5.Suzuki T, Osada H, Takeda T, Yamazaki K, Minatoya K. Pseudoaneurysm arising from a side branch of a graft for ascending aortic replacement. JTCVS Tech. 2023 Jul 20;21:32-34. doi: 10.1016/j.xjtc.2023.07.004. eCollection 2023 Oct.
- 6.Heima D, Takeda M, Tabata Y, Minatoya K, Yamashita JK, Masumoto H. Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device. J Thorac Cardiovasc Surg. 2023 Nov 21:S0022-5223(23)01095-4. doi: 10.1016/j.jtcvs.2023.11.019. Online ahead of print.
- 7.Osada H, Minatoya K. Minimal access aortic surgery. Indian J Thorac Cardiovasc Surg. 2023 Dec;39(Suppl 2):346-348. doi: 10.1007/s12055-023-01578-5. Epub 2023 Aug 17.
- 8.Osada H, Minatoya K. Overview of acute type A dissection in Japan. Indian J Thorac Cardiovasc Surg. 2023 Dec;39(Suppl 2):280-286. doi: 10.1007/s12055-023-01548-x. Epub 2023 Jul 19.
- 9.Osada H, Yamazaki K, Takeda T, Minatoya K. Vascular graft infection with duodenal fistulisation ten years after hybrid endovascular aortic repair with renal visceral debranching. General Thorac Cardiovasc Surg Cases. 2, 83 (2023). https://doi.org/10.1186/s44215-023-00087-6
- 10. Murata K, Makino A, Tomonaga K, Masumoto H. Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. iScience. 2023 Dec 22;27(1):108641.
- 2022年
- 1.Kozue Murata, Hidetoshi Masumoto. Systems for the functional evaluation of human heart tissues derived from pluripotent stem cells. Stem Cells, 18 March 2022, https://doi.org/10.1093/stmcls/sxac022
- 2.Yamazaki K, Minatoya K. Tear-oriented strategy to avoid tears of patients and surgeons. Eur J Cardiothorac Surg. 2022 May 2;61(5):1085-1086. doi: 10.1093/ejcts/ezab526.
- 3.Minatoya K. Commentary: Detailed assessment of hidden risks of postoperative delirium. JTCVS Open. 2022 Apr 19;10:97-98. doi: 10.1016/j.xjon.2022.04.021. eCollection 2022 Jun.
- 4.Minatoya K. Is this the final answer for the aortopathy with bicuspid aortic valve. J Card Surg. 2022 Aug;37(8):2336-2337. doi: 10.1111/jocs.16589. Epub 2022 May 8.
- 5.Yamazaki K, Minatoya K. Looking for a medication that suppresses the expansion of the ascending aorta. Eur J Cardiothorac Surg. 2022 Jan 24;61(2):393-394. doi: 10.1093/ejcts/ezab522.
- 6.Osada H, Kanemitsu H, Sakai J, Kumagai M, Yamazaki K, Minatoya K. Asymptomatic pseudoaneurysm 8 years after valve-sparing aortic root replacement. JTCVS Tech. 2022 Jun 16;14:48-49. doi: 10.1016/j.xjtc.2022.06.003. eCollection 2022 Aug.
- 7.Yamazaki K, Minatoya K, Kumagai M, Handa T, Ohsumi A, Torishima M, Kawasaki H. Valve-sparing Aortic Root Replacement for a Patient With Filamin A Mutation. Ann Thorac Surg. 2022 May;113(5):e397. doi: 10.1016/j.athoracsur.2021.12.037. Epub 2022 Jan 13.
- 8.Konegawa Y, Kuwahara T, Jo JI, Murata K, Takeda T, Ikeda T, Minatoya K, Masumoto H, Tabata Y. Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction. Eur J Cardiothorac Surg. 2022 Oct 4;62(5):ezac414. doi: 10.1093/ejcts/ezac414.
- 9.Fujiwara Y, Hirao S, Yamazaki K, Ikeda T, Minatoya K, Masumoto H. Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models. J Artif Organs. 2022 Mar;25(1):24-33. doi: 10.1007/s10047-021-01283-3. Epub 2021 Jun 18.
- 10.Kyo S, Murata K, Kawatou M, Minatoya K, Sunagawa GA, Masumoto H. Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest. JTCVS Open. 2022 Nov 8;12:201-210. doi: 10.1016/j.xjon.2022.11.001. eCollection 2022 Dec.
- 11.Ho WJ, Kobayashi M, Murata K, Hashimoto Y, Izumi K, Kimura T, Kanemitsu H, Yamazaki K, Ikeda T, Minatoya K, Kishida A, Masumoto H. A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture. Sci Rep. 2022 Dec 24;12(1):22294. doi: 10.1038/s41598-022-26792-w.
- 12.Sakai J, Minatoya K, Yamazaki K, Kanemitsu H. Single-stage repair of the right aortic arch with Kommerell diverticulum through the right thoracotomy with SIRC approach. Gen Thorac Cardiovasc Surg. 2022 May;70(5):498-500. doi: 10.1007/s11748-022-01781-y. Epub 2022 Jan 31..
- 2021年
- 1.Kawatou M, Minatoya K, Yamazaki K, Kanemitsu H, Sakamoto K, Sakai J. A case report of valve-sparing aortic root replacement in a patient with full metal jacket aorta. J Vis Surg 2020 Nov Online First doi: 10.21037/jovs-20-108 View this article at: http://dx.doi.org/10.21037/jovs-20-108
- 2.Osada H, Minatoya K. Updates in aortic wall pathology. Surg Today. 2021 Nov30. doi: 10.1007/s00595-021-02420-4. Epub ahead of print. PMID: 34845508.
- 3.Minatoya K. Commentary: Strike a Happy Medium. Semin Thorac Cardiovasc Surg. 2021 Dec 21:S1043-0679(21)00502-5. doi: 10.1053/j.semtcvs.2021.12.010. Epub ahead of print. PMID: 34952154.
- 4.Minatoya K. Commentary: Find first, seek later. J Thorac Cardiovasc Surg. 2021 Oct;162(4):1046-1047. doi: 10.1016/j.jtcvs.2020.02.130. Epub 2020 Mar 19. PMID: 32279966.
- 5.Minatoya K. Commentary: Use it or lose it. J Thorac Cardiovasc Surg. 2021 Jun;161(6):2014-2015. doi: 10.1016/j.jtcvs.2019.11.099. Epub 2019 Dec 12. PMID:31959449.
- 6.Minatoya K. Commentary: Fighting With Atherosclerotic Aortic Wall. Semin Thorac Cardiovasc Surg. 2021 Oct 2:S1043-0679(21)00431-7. doi:10.1053/j.semtcvs.2021.09.016. Epub ahead of print. PMID: 34610454.
- 7.Minatoya K. The reality of the treatment for acute aortic dissection in a megacity. Eur J Cardiothorac Surg. 2021 Oct 22;60(4):965-966. doi:10.1093/ejcts/ezab261. PMID: 34077497.
- 8.Yamazaki K, Minatoya K. Tear-oriented strategy to avoid tears of patients and surgeons. Eur J Cardiothorac Surg. 2021 Dec 8:ezab526. doi:10.1093/ejcts/ezab526. Epub ahead of print. PMID: 34878115.
- 9.Minatoya K. Impact of renal dysfunction on arch replacement in a database study. Eur J Cardiothorac Surg. 2021 Dec 27;61(1):170-171. doi:10.1093/ejcts/ezab329. PMID: 34322710.
- 10.Kumagai M, Nishizawa J, Takehara M, Shinoda E, Minatoya K. Surgical management of a giant atrial septal aneurysm. Clin Case Rep. 2021 May 5;9(5):e04125. doi: 10.1002/ccr3.4125. PMID: 34026164; PMCID: PMC8123557.
- 11.Yamazaki K, Minakata K, Nakane T, Kinoshita H, Tanizawa K, Sumiyoshi S, Sato H, Minatoya K, Sakata R. A rare case of primary angiosarcoma of the anterior mediastinum. Gen Thorac Cardiovasc Surg. 2021 Apr;69(4):766-769. doi:10.1007/s11748-020-01551-8. Epub 2020 Nov 22. PMID: 33222090.
- 12.Ide Y, Tachimori H, Hirata Y, Hirahara N, Ota N, Sakamoto K, Ikeda T, Minatoya K. Risk analysis for patients with a functionally univentricular heart after systemic-to-pulmonary shunt placement. Eur J Cardiothorac Surg. 2021 Jul 30;60(2):377-383. doi: 10.1093/ejcts/ezab077. PMID: 33712829.
- 13.Minatoya K. Aggressive strategy to save the brain in a case of acute aortic dissection. J Card Surg. 2021 Oct;36(10):3981-3982. doi: 10.1111/jocs.15874. Epub 2021 Jul 28. PMID: 34322913.
- 14.Yamazaki K, Minakata K, Nakane T, Kawatou M, Minatoya K, Sakata R. Thyroid storm after mitral valve repair in a patient with Becker muscular dystrophy. J Card Surg. 2021 Feb;36(2):739-742. doi: 10.1111/jocs.15245. Epub 2020 Dec 11. PMID: 33305858.
- 15.Kurokawa S, Hashimoto Y, Funamoto S, Murata K, Yamashita A, Yamazaki K, Ikeda T, Minatoya K, Kishida A, Masumoto H. In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model. PLoS One. 2021 Jul 22;16(7):e0254160. doi: 10.1371/journal.pone.0254160. PMID: 34292963; PMCID: PMC8297896.
- 16. Osada H, Kawatou M, Fujita D, Tabata Y, Minatoya K, Yamashita JK, Masumoto H. Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues. JTCVS Open 2021;8:359-74, doi: https://doi.org/10.1016/j.xjon.2021.09.038.
- 17. Masumoto H. Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages. Methods Mol Biol. 2021;2320:81-88. doi: 10.1007/978-1-0716-1484-6_9.
- 2020年
- 1.Minatoya K. Commentary: Always do right. J Thorac Cardiovasc Surg. 2020 Mar;159(3):779-780. doi: 10.1016/j.jtcvs.2019.03.101. Epub 2019 Apr 24. PMID:31126659.
- 2.Minatoya K. Commentary: Find first, seek later. J Thorac Cardiovasc Surg. 2020 Mar 19:S0022-5223(20)30622-X. doi: 10.1016/j.jtcvs.2020.02.130. Epub ahead of print. PMID: 32279966.
- 3.Murata K, Ikegawa M, Minatoya K, Masumoto H. Strategies for immune regulation in iPS cell-based cardiac regenerative medicine. Inflamm Regen. 2020 Sep 29;40:36. doi: 10.1186/s41232-020-00145-4. PMID: 33005258; PMCID: PMC7523082.
- 4.Minatoya K. Commentary: A superb and meticulous technique, but needs cautious, lifelong follow-up. J Thorac Cardiovasc Surg.2020 Feb; 159(2): e101-e102.doi: 10.1016/j.jtcvs.2019.09.056. Epub 2019 Sep 24. PMID:31653419.
- 5.Yamazaki K, Minakata K, Nakane T, Kinoshita H, Tanizawa K, Sumiyoshi S, Sato H, Minatoya K, Sakata R. A rare case of primary angiosarcoma of the anterior mediastinum. Gen Thorac Cardiovasc Surg. 2020 Nov 22. doi:10.1007/s11748-020-01551-8. Epub ahead of print. PMID: 33222090.
- 6.Yamazaki K, Minatoya K, Sakamoto K, Kitagori K, Okuda M, Murakami K. Hypothermic circulatory arrest for aortic dissection with cryoglobulinemia. J Card Surg. 2020 Nov;35(11):3169-3172. doi: 10.1111/jocs.14908. Epub 2020 Jul 28. PMID: 32725644.
- 7.Yamazaki K, Minakata K, Sakamoto K, Sakai J, Ide Y, Kawatou M, Kanemitsu H, Ikeda T, Minatoya K, Sakata R. A case of aggressive aortic prosthetic valve endocarditis aggressive caused by Staphylococcus lugdunensis. Surg Case Rep. 2020 Nov 5;6(1):280. doi: 10.1186/s40792-020-01062-x. PMID: 33151421; PMCID:PMC7644629.
- 8.Osada H, Kawatou M, Takeda M, Jo JI, Murakami T, Tabata Y, Minatoya K, Yamashita JK, Masumoto H. Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model. Heliyon. 2020 Jul 13;6(7):e04423. doi: 10.1016/j.heliyon.2020.e04423. PMID: 32685738; PMCID: PMC7358391.
- 9.Nagasawa A, Masumoto H, Yanagi S, Kanemitsu N, Ikeda T, Tabata Y, Minatoya K. Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model. Gen Thorac Cardiovasc Surg. 2020 Apr;68(4):311-318. doi:10.1007/s11748-019-01187-3. Epub 2019 Aug 13. PMID: 31410725.
- 10.Abulaiti M, Yalikun Y, Murata K, Sato A, Sami MM, Sasaki Y, Fujiwara Y, Minatoya K, Shiba Y, Tanaka Y, Masumoto H. Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function. Sci Rep. 2020 Nov 5;10(1):19201. doi: 10.1038/s41598-020-76062-w. PMID: 33154509; PMCID: PMC7645446.
- 11.Yamazaki K, Minakata K, Nakane T, Kawatou M, Minatoya K, Sakata R. Thyroid storm after mitral valve repair in a patient with Becker muscular dystrophy. J Card Surg. 2020 Dec 11. doi: 10.1111/jocs.15245. Epub ahead of print. PMID:33305858.
- 12.Itonaga T, Hirao S, Yamazaki K, Ikeda T, Minatoya K, Masumoto H. The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model. Gen Thorac Cardiovasc Surg. 2020 Aug;68(8):785-792. doi: 10.1007/s11748-020-01292-8. Epub 2020 Jan 18. PMID: 31955320.
- 13.Takai F, Takeda T, Yamazaki K, Ikeda T, Hyon SH, Minatoya K, Masumoto H. Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (L-lysine)-based biocompatible glue. Gen Thorac Cardiovasc Surg. 2020 Aug;68(8):793-800. doi: 10.1007/s11748-020-01297-3. Epub 2020 Jan 24. PMID: 31981138.
- 14.Nishio H, Minatoya K, Masumoto H. A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure. J Vis Exp. 2020 May 15;(159). doi:10.3791/60931. PMID: 32478716.
- 15.Nakane T, Abulaiti M, Sasaki Y, Kowalski WJ, Keller BB, Masumoto H. Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair. J Vis Exp. 2020 Jun 9;(160). doi: 10.3791/61246. PMID: 32597877.
- 16.Osada H, Ho WJ, Yamashita H, Yamazaki K, Ikeda T, Minatoya K, Masumoto H. Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator. Regen Ther. 2020 Nov 2020;15:258-264 doi:org/10.1016/j.reth.2020.10.007. PMID: 33426227. PMCID: PMC7770426.
- 2019年
- 1.Minatoya K. Commentary: A superb and meticulous technique, but needs cautious, lifelong follow-up. J Thorac Cardiovasc Surg. 2019 Sep 24. pii: S0022-5223(19)32053-7. doi: 10.1016/j.jtcvs.2019.09.056. [Epub ahead of print] No abstract available.
- 2.Minatoya K. Reply: Finding the best option of the cannulation site. J Thorac Cardiovasc Surg. 2019 Aug 20. pii: S0022-5223(19)31500-4. doi: 10.1016/j.jtcvs.2019.07.035. [Epub ahead of print] No abstract available.
- 3.Nagasawa A, Masumoto H, Yanagi S, Kanemitsu N, Ikeda T, Tabata Y, Minatoya K. Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model. Gen Thorac Cardiovasc Surg. 2019 Aug 13. doi: 10.1007/s11748-019-01187-3. [Epub ahead of print]
- 4.Nakatsu T, Minakata K, Tanaka S, Minatoya K; PROGRESS-Kyoto Investigators. Intermediate-term outcomes of aortic valve replacement with bioprosthetic or mechanical valves in patients on hemodialysis. J Thorac Cardiovasc Surg. 2019 Jun;157(6):2177-2186.e3. doi: 10.1016/j.jtcvs.2018.08.104. Epub 2018 Sep 28.
- 5.Nishio H, Masumoto H, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K. MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model. J Thorac Cardiovasc Surg. 2019 Jun;157(6):2242-2251. doi: 10.1016/j.jtcvs.2018.08.115. Epub 2018 Oct 6.
- 6.Minatoya K. Commentary: Always do right. J Thorac Cardiovasc Surg. 2019 Apr 24. pii: S0022-5223(19)30879-7. doi: 10.1016/j.jtcvs.2019.03.101. [Epub ahead of print] No abstract available.
- 7.Minatoya K, Inoue Y, Sasaki H, Tanaka H, Seike Y, Oda T, Omura A, Iba Y, Ogino H, Kobayashi J. Total arch replacement using a 4-branched graft with antegrade cerebral perfusion. J Thorac Cardiovasc Surg. 2019 Apr;157(4):1370-1378. doi: 10.1016/j.jtcvs.2018.09.112. Epub 2018 Oct 17.
- 8.Ueyama K, Miyahara S, Ide Y, Sakamoto K, Kanemitsu H, Yamazaki K, Ikeda T, Aoyama A, Date H, Minatoya K. On-pump beating CABG concomitant with bilateral living-donor lobar lung transplantation. Heart Lung. 2019 Mar - Apr;48(2):166-168. doi: 10.1016/j.hrtlng.2018.08.008. Epub 2018 Oct 5. No abstract available.
- 9.Minatoya K, Inoue Y, Seike Y, Omura A, Uehara K, Sasaki H, Matsuda H, Kobayashi J. Thoracoabdominal aortic replacement in patients aged 50 and younger. Gen Thorac Cardiovasc Surg. 2019 Jan;67(1):53-58. doi: 10.1007/s11748-018-0917-y. Epub 2018 Apr 2.
- 2018年
- 1.Yamazaki K, Minatoya K, Ueda R, Takehara M, Sakamoto K, Ide Y, Kanemitsu H, Ueyama K, Ikeda T. Valve-sparing Replacement in Patients with Aortic Root Dilatation. Kyobu Geka. 2018 Jan;71(1):19-24.
- 2.Minatoya K. Con: "Debate: does every ascending aorta repair require at least an open distal anastomosis at the innominate? Or not?" J Vis Surg. 2018 Mar 13;4:49.
- 3.Hirao S, Masumoto H, Itonaga T, Minatoya K. A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats. J Vis Exp. 2018 Mar 23;(133).
- 4.Minatoya K, Inoue Y, Seike Y, Omura A, Uehara K, Sasaki H, Matsuda H, Kobayashi J. Thoracoabdominal aortic replacement in patients aged 50 and younger. Gen Thorac Cardiovasc Surg. 2018 Apr 2. [Epub ahead of print]
- 5.Minatoya K. Setting body temperature during aortic arch surgery. J Vis Surg. 2018;4: 176.
- 6.Minatoya K, Nakatsu T, Yamazaki K, Ikeda T. Total aortic replacement in an adolescent case. J Vis Surg 2018;4:186
- 7.Kumagai M, Minakata K, Masumoto H, Yamamoto M, Yonezawa A, Ikeda T, Uehara K, Yamazaki K, Ikeda T, Matsubara K, Yokode M, Shimizu A, Tabata Y, Sakata R, Minatoya K. A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model. Heart Vessels. 2018 May 14. [Epub ahead of print]
- 8.Ishigami M, Masumoto H, Ikuno T, Aoki T, Kawatou M, Minakata K, Ikeda T, Sakata R, Yamashita JK, Minatoya K. Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts. PLoS One. 2018 Aug 2;13(8): e0201650
- 9.Tsumaru S, Masumoto H, Minakata K, Izuhara M, Yamazaki K, Ikeda T, Ono K, Sakata R, Minatoya K. Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia. J Vasc Surg. 2018 Oct;68(4):1209-1215.
- 10.Ueyama K, Miyahara S, Ide Y, Sakamoto K, Kanemitsu H, Yamazaki K, Ikeda T, Aoyama A, Date H, Minatoya K. On-pump beating CABG concomitant with bilateral living-donor lobar lung transplantation. Heart&Lung. 2018 Oct 4. pii: S0147-9563(18)30295-4. [Epub ahead of print]
- 11.Nishio H, Masumoto H, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K. MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model. J Thorac Cardiovasc Surg. 2018 Oct 6. pii: S0022-5223(18)32515-7. [Epub ahead of print]
- 12.Minatoya K, Inoue Y, Sasaki H, Tanaka H, Seike Y, Oda T, Omura A, Iba Y, Ogino H, Kobayashi J. Total arch replacement using a 4-branched graft with antegrade cerebral perfusion. J Thorac Cardiovasc Surg. 2018 Oct 17. [Epub ahead of print]
- 13.Masumoto H, Yamashita JK. Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft. Inflamm Regen. 2018 Oct 10;38:26.
- 14. Li Z, Masumoto H, Jo JI, Yamazaki K, Ikeda T, Tabata Y, Minatoya K. Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular. Gen Thorac Cardiovasc Surg. 2018 Nov;66(11):641-647.
- 2017年
- 1.Hirao S, Minakata K, Masumoto H, Yamazaki K, Ikeda T, Sakata R. Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg. 2017;154(6):1973-1983
- 2.Kawatou M, Minakata K, Sakamoto K, Nakatsu T, Tazaki J, Higami H, Uehara K, Yamazaki K, Inoue K, Kimura T, Sakata R. Comparison of endovascular repair with branched stent graft and open repair for aortic arch aneurysm†.Interact Cardiovasc Thorac Surg. 2017;25(2):246-253
- 3.Ikuno T, Masumoto H, Yamamizu K, Yoshioka M, Minakata K, Ikeda T, Sakata R, Yamashita JK. Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP. PLoS One.2017;12(4)
- 4.Minakata K, Tanaka S, Tamura N, Yanagi S, Ohkawa Y, Okonogi S, Kaneko T, Usui A, Abe T, Shimamoto M, Takahara Y, Yamanaka K, Yaku H, Sakata R. Comparison of the Long-Term Outcomes of Mechanical and Bioprosthetic Aortic Valves - A Propensity Score Analysis. Circ J.2017;81(8):1198-1206
- 5.Uehara K, Minakata K, Saito N, Imai M, Daijo H, Nakatsu T, Sakamoto K, Yamazaki K, Kimura T, Sakata R. Use of extracorporeal membrane oxygenation in complicated transcatheter aortic valve replacement.Gen Thorac Caediovasc Surg.2017;65(6)329-336
- 6.Taki T, Masumoto H, Funamoto M, Minakata K, Yamazaki K, Ikeda T, Sakata R. Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg.2017:153(3):726-734
- 7.Setozaki S, Minakata K, Masumoto H, Hirao S, Yamazaki K, Kuwahara K, Ikeda T, Sakata R. Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model.J Vasc Surg.2017;65(6):1803-1812
- 8.Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita J.K. Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun.2017;8(1):1078
- 9.Nakane T, Masumoto H, Tinney JP, Yuan F, Kowalski WJ, Ye F, LeBlanc AJ, Sakata R, Yamashita JK, Keller BB. Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue. Sci Rep. 2017;7:45641
- 10.Masumoto H, Yamashita JK. Untiring step toward the maturation of human stem cell-engineered heart tissue. Ann Transl Med. 2017;5(4):87
- 11.Tsumaru S, Masumoto H, Minakata K, Izuhara M, Yamazaki K, Ikeda T, Ono K, Sakata R, Minatoya K. Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia. J Vasc Surg. [Epub ahead of print]
- 12.Minatoya K. Keep Alert Eyes on Delayed Paraplegia. Semin Thorac Cardiovasc Surg. [Epub ahead of print]
- 13.Hirao S, Masumoto H, Minatoya K. Rat Cardiopulmonary Bypass Models to Investigate Multi-Organ Injury. Clin Surg. 2017;2:1509
- 14.Hirao S, Masumoto H, Itonaga T, Minatoya K. A recovery cardiopulmonary bypass model without transfusion or inotropic agents in rats. J Vis Exp. [Epub ahead of print]
現在実施中の臨床研究
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- 1. 日本における成人心臓血管外科手術のレジストリ
- 2. 日本における補助人工心臓に関連した市販後のデータ収集(J-MACSレジストリ研究)
- 3. 末期腎不全患者に対する大動脈弁人工弁置換術の遠隔成績に関する多施設共同研究
- 4. 虚血性心疾患に対する冠状動脈バイパス術の有効性評価に関する研究
- 5. 大動脈弁置換術における心房細動に対する外科的アブレーションの有効性についての多施設共同後ろ向き研究
- 6. 心臓血管外科手術施行患者からの切除標本を用いた心血管系細胞および組織の特性解析研究

